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Application Notes
Our database of GPC/SEC application notes explain the use of concentration, viscometer and light scattering detectors to obtain a distribution of absolute molecular weight, size and intrinsic viscosity, as well as information on conformation, aggregation, branching and copolymer characterization.
 
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TDAmax GPC Systems
TDAmaxTM Elevated Temperature GPC System
The TDAmax will provide absolute molecular weight, molecular size, intrinsic viscosity, and copolymer characterization.
The Viscotek TDAmax is a comprehensive and powerful advanced detector Gel Permeation/Size Exclusion Chromatography system with temperature control from ambient to 80°C. It is specifically designed for the characterization of natural and synthetic polymers, copolymers, proteins, nanoparticles and other macromolecules. As the world’s only fully integrated, advanced detector system available from a single vendor, the TDAmax sets the benchmark for GPC technology and is configured as follows:
  • Integrated Triple Detector Array featuring a revolutionary Low Angle Light Scattering (LALS) Detector, four-capillary Differential Viscometer and Differential Refractive Index (RI) Detector.
  • GPCmax™ Pump/Autosampler/Degasser Module for automated solvent and sample delivery.
  • OmniSEC™ GPC/SEC software for complete system control.
The TDAmax will provide absolute molecular weight without extrapolation or correction, molecular size (Rh to less than 1 nm and Rg) and intrinsic viscosity, as well as information on structure, conformation, aggregation and branching in a single GPC/SEC experiment. By adding a UV/VIS Detector and creating an integrated Tetra Detector Array, the TDAmax will also provide information on copolymer characterization.


Triple and Tetra Detector Array

The Viscotek Triple and Tetra Detector Arrays provide comprehensive copolymer characterization The Viscotek Triple and Tetra Detector Arrays combine low angle light scattering with viscometry and concentration for complete and comprehensive macromolecular characterization. All detectors reside within a temperature-controlled oven compartment (ambient to 80°C) which also has space for 3-5 analytical GPC columns. This arrangement minimizes inter-detector volumes to reduce band-broadening effects and insures that detectors, inter-detector tubing, columns and sample reside at the same temperature throughout the course of the analysis.



The GPCmax integrated pump, autosampler and degasser module simplify copolymer characterization GPCmax™

The GPCmax is a unique, integrated pump, autosampler and degasser module specifically designed for GPC/SEC applications. It features a variable injection volume autosampler capable of handling 2 ml or 20 ml vials, an isocratic pump for pulseless and reproducible solvent flow and an in-line solvent degasser. The GPCmax is controlled by the OmniSEC software and mates seamlessly with either the Triple or Tetra Detector Array to form a complete GPC/SEC system.

OmniSEC™ Software

The OmniSEC software increases the efficiency of copolymer characterizationOmniSEC is a powerful and flexible GPC/SEC software program specifically designed to maximize the information content and efficiency of the multiple detector chromatography experiment. Key features include interactive programs for calculation of results in a real-time time environment, automatic baseline and peak detection, multiple peak analysis, copolymer and conjugate compositional analysis and determination of A2 and B22 values. OmniSEC allows full control of the Triple and Tetra Detector Arrays and GPCmax, along with data acquisition, processing and export, and is 21 CFR part 11 compliant.

For more information, including full technical specifications, performance information and product details, please click below to download our product brochure.

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Complete Gel Permeation Chromatography (GPC) / Size Exclusion Chromatography (SEC) systems for the characterization of natural and synthetic polymers, proteins, conjugates and excipients. Integrated Triple and Tetra Detector Arrays (TDAs) featuring Low Angle Light Scattering (LALS) detectors, four capillary differential viscometer detectors, refractometers and UV/VIS detectors; in a single experiment, obtain absolute molecular weight, molecular size, intrinsic viscosity, conformation, polymer branching, aggregation, and copolymer characterization. Flow Injection Polymer Analysis (FIPA) for fast, accurate and precise average molecular weight, size and intrinsic viscosity in routine QA/QC and process control. Automated Dilute Solution Viscosity (DSV) systems provide relative, inherent, and intrinsic viscosity.